Healthy Urinary Tract Support*

Delivers per Serving (1 Scoop About 1.6 g):

  • 50 mg Vitamin C (as Ascorbic Acid) 
  • 250 mg Cranberry Fruit
  • 50 mg D-Mannose
  • 100 Million CFU Lactobacillus reuteri 1E1

Optimize Early-Life Health with ChildLife® Clinicals Kidney/Urinary Health.

Key Benefits*

  • SUPPORTS urinary tract health
  • PROVIDES benefits from whole cranberry
  • OPTIMIZES natural factors for immune health
  • PROMOTES maintenance for whole-body wellness

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Purpose:  To provide clinicians with technical information to determine if the supplement in question is appropriate for their patient.   

Kidney/Urinary Health

ChildLife® Clinicals Kidney/Urinary Health is a ready-to-mix supplemental powder that provides ingredients which may support urinary tract health. 

Children’s Urinary Tract Health

Urinary Tract Infections are common among children, with 3% of children diagnosed annually.1

An infection occurs when bacteria invade the urinary tract, and the pathogen overcomes the body’s natural defense mechanisms. The treatment is typically antibiotic use. However, over-use of antibiotics in children is undesirable, and therefore supporting a healthy urinary tract and taking the possible measures to avoid infection, rather than treat, is preferable.

Vitamin C

Vitamin C is known for its antioxidant activity, and contribution to a healthy immune system.2 Included in this formula is Vitamin C, in the form of Ascorbic Acid, for optimal maintenance and health. Some research suggests a role for Vitamin C in reducing the growth of bacteria in the urine. This has been attributed to the chemical ability of ascorbic acid to reduce the pH of urine, as well as contribute to nitrite concentration, which has an inhibitory effect on bacteria.3 Further studies are required to validate effectiveness of Vitamin C for urinary support however, intake of Vitamin C has been determined to support the immune system in general.

Cranberry Fruit

Cranberries are a rich source of nutrients and phytonutrients.4 Cranberries contain the compounds proanthocyanidins (PACs) and studies have shown that A-Type proanthocyanidin compounds in cranberries have the ability to prevent E. coli bacteria from adhering to the epithelium of the urinary tract.5,6 Consuming cranberries may be beneficial for maintaining health. Whole cranberry fruit powder is included in this formula.

D-Mannose

Mannose, which is a natural monosaccharide with metabolic activity, can be taken as a dietary supplement. The excess mannose is excreted in urine. Studies show mannose has the ability to inhibit E. coli adherence to urinary tract epithelial wall.7Supplementing with D-Mannose may support a healthy urinary tract. 

Lactobacillus reuteri 1E1

Probiotics have been used to enhance the number of beneficial bacteria in microbiomes. Certain probiotics have the ability to antagonize pathogenic bacteria by producing antimicrobial compounds. The probiotic L. reuteri has been studied for its ability to inhibit pathogenic bacteria, and support the immune system.8

Supplementation with a combination of natural ingredients which support the immune system, may be beneficial to certain individuals. 

References: 

  1. Hatch D, Hulbert W. Pediatric urinary tract infections. American Urological Association website. https://www.auanet.org/education/pediatric-urinary-tract-infections.cfm External link. Updated July 2016.
  2. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211.
  3. Carlsson S, Wiklund NP, Engstrand L, Weitzberg E, Lundberg JO. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide.2001;5(6):580-6.
  4. Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris-Etherton, P., Howell, A., Manach, C., … Vita, J. A. (2013). Cranberries and their bioactive constituents in human health. Advances in nutrition (Bethesda, Md.), 4(6), 618–632. doi:10.3945/an.113.004473. 
  5. Howell AB, Vorsa N, Der Marderosian A, Foo LY. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Engl J Med.1998;339:1085–6.
  6. Gupta A, Dwivedi M, Mahdi AA, Nagana Gowda GA, Khetrapal CL, Bhandari M. Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin.Urol Res.2012;40(2):143-50. doi: 10.1007/s00240-011-0398-2. 
  7. Domenici L, Monti M, Bracchi C, Giorgini M, Colagiovanni V, Muzii L, Benedetti Panici P. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci.2016;20(13):2920-5.
  8. Mu, Q., Tavella, V. J., & Luo, X. M. (2018). Role of Lactobacillus reuteri in Human Health and Diseases. Frontiers in microbiology, 9, 757. doi:10.3389/fmicb.2018.00757.