Healthy Respiratory Support*

Vitamins + Nutrients + Herbs
Delivers per Serving (1 mL):

  • 50 mg Vitamin C (as Ascorbic Acid)
  • 10 mg Vitamin B6 (as Pyridoxine HCL)
  • 297 mg Proprietary Herbal Blend:
    • Fresh Osha Root
    • Ivy Leaf Extract
    • Nettle Leaf
    • Peppermint Leaf
    • Licorice Root
    • Sophora Root
    • Fresh Yerba Santa Leaf
    • Stevia Leaf
    • Reishi Mushroom Fruiting Body

Optimize Early-Life Health with ChildLife® Clinicals Lung Health.

Key Benefits*

  • COMBINES traditional chinese herbs, western herbs, and vitamins
  • SUPPORTS respiratory system health
  • PROVIDES multiple ingredients with antioxidant potential
  • DELIVERS healthy lung support in every serving

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Purpose: To provide clinicians with technical information to determine if the supplement in question is appropriate for their patient.

Lung Health

ChildLife® Clinicals Organic Lung Health is a liquid dietary supplement consisting of a combination of herbal ingredients and vitamins, to support a healthy respiratory system.

Childhood Respiratory Conditions

Respiratory conditions in children are significant, with asthma being a major concern. Currently, 8.4% or approximately 1 in 12 children are diagnosed asthmatic.1

Anti-Asthma Herbal Medicine Intervention

Studies have supported herbal ingredient use for respiratory support. A study appearing in the Journal of Allergy and Clinical Immunology demonstrated effective respiratory support for asthmatic patients, through supplementation of a traditional Chinese medicine three herb blend.2 Named Anti-Asthma Herbal Medicine Intervention (ASHMI), their formula includes Ling-Zhi (Reishi), Ku-Shen (Sophora), and Gan-Cao (Chinese Licorice).2 The study showed significant improvements in lung function. Along with previously published studies, the team concluded ASHMI effectively inhibited smooth muscle contractions within the respiratory tract and, unlike steroidal treatments, has an immunomodulatory effect with no known side effects to date.2,3 ChildLife® Clinicals Lung Health formula includes two of the key components of ASHMI, for respiratory support.

Bronchodilation

Shrubby Sophora (Sophora flavescens) contains bioactive compounds. In particular, the flavonoid trifolirhizin has demonstrated ability to inhibit
acetylcholine-induced contractions of airway smooth muscle.4 Further, a study revealed the vascular dilation mechanism of trifolirhizin as acting on the nitrous oxide pathway.5

English Ivy (Hedera helix) has been used traditionally for respiratory conditions. Several studies on ivy leaf for respiratory conditions showing positive results, including a study of over 5,000 children with bronchitis, lend its safety and efficacy for application as an herbal respiratory supplement.6 A compound in ivy, alpha-hederin, may involve the beta-2 adrenoreceptor for bronchial smooth muscle relaxation.7

Anti-inflammatory, Anti-Allergic, & Antioxidants

Included in this blend are the following herbs:

Osha (Ligusticum porteri), a western herb with immune modulating and antioxidant potential.8,9

Yerba Santa (Eriodictyon californicum) has shown antiallergic potential in animal models, with the eriodictyol compound effecting inhibition of the
allergic response.10

Reishi (Ganoderma Lucidum) has shown immunomodulatory effects and is one of the key components in the Anti Asthma Herbal Medicine formula.11,2

Animal studies have validated the use of Stinging Nettle (Urtica dioica) as a natural antiasthmatic agent.12

Peppermint (Mentha x piperita) contains flavonoid glycosides which may have antiallergic properties.13

Licorice Root (Glycyrrhiza glabra) contains flavanone compounds which give licorice its antioxidant and anti-inflammatory properties.14

Lastly, supplementation with Vitamin C may help shorten the duration of upper respiratory tract infections.15

References: 

  1. Asthma Surveillance Data. Centers for Disease Control and Prevention. https://www.cdc.gov/asthma/asthmadata.htm. Published March 25, 2019.
  2. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, Mu DZ, Du JB, Li GH, Wallenstein S, Sampson H, Kattan M, Li XM. Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005;116:517–524.
  3. Srivastava K, Sampson HA, Emala CW Sr, Li XM. The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors. Am J Physiol Lung Cell Mol Physiol. 2013;305(12):L1002–L1010.
  4. Yang N, Liang B, Srivastava K, et al. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry. 2013;95:259–267. doi:10.1016/j.phytochem.2013.07.023.
  5. Kang DG, Lee X, Lee JK, Choi DH, Chai KY, Lee HS. Trifolirhizin and desmethylicaritin, active components of roots of Sophora flavescens AIT., induced vascular relaxation via NO/cGMP signaling. The FASEB Journal. 2007;21:6, A1240-A1240.
  6. Fazio S, Pouso J, Dolinsky D, Fernandez A, Hernandez M, Clavier G, Hecker M. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine. 2009;16(1):17-24.
  7. Wolf A, Gosens R, Meurs H, Häberlein H.Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle. Phytomedicine. 2011;18(2-3):214-8.
  8. Nguyen K, Sparks J, Omoruyi FO. Investigation of the cytotoxicity, antioxidative and immune-modulatory effects of Ligusticum porteri (Osha) root extract on human peripheral blood lymphocytes. J Integr Med. 2016;14(6):465-472. doi: 10.1016/S2095-4964(16)60280-7.
  9. Nguyen K, Sparks J, Omoruyi F. Effects of Ligusticum porteri (Osha) Root Extract on Human Promyelocytic Leukemia Cells. Pharmacognosy Res. 2017;9(2):156–160. doi:10.4103/0974-8490.204641.
  10. Yoo JM, Kim JH, Park SJ, Kang YJ, Kim TJ. Inhibitory effect of eriodictyol on IgE/Ag-induced type I hypersensitivity. Biosci Biotechnol Biochem. 2012;76(7):1285-90.
  11. Wang X, Lin Z. Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism. Adv Exp Med Biol. 2019;1182:1-37.
  12. Zemmouri H, Sekiou O, Ammar S, et al. Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model. Pharm Biol. 2017;55(1):1561–1568.
  13. Inoue T, Sugimoto Y, Masuda H, Kamei C. Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L. Biol Pharm Bull. 2002;25(2):256-9.
  14. Frattaruolo L, Carullo G, Brindisi M, et al. Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway. Antioxidants (Basel). 2019;8(6):186.
  15. Vorilhon P, Arpajou B, Vaillant Roussel H, Merlin É, Pereira B, Cabaillot A.Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. Eur J Clin Pharmacol. 2019;75(3):303-311. doi: 10.1007/s00228-018-2601-7.